
Clinical TrialApr 13, 2026, 08:01 AM
LIXTE's LB-100/Dostarlimab Trial Shows 40% DCR in Ovarian Cancer
AI Summary
LIXTE Biotechnology announced preliminary clinical trial results for its LB-100 compound combined with Dostarlimab for ovarian clear cell carcinoma. The trial showed an acceptable safety profile and a 40% Disease Control Rate (DCR) among 20 evaluated patients. With a median follow-up of 12 months, the overall survival probability was 0.69 at 12 months, offering new hope for patients with limited therapeutic options. An additional cohort of 21 patients is now enrolling to test higher LB-100 exposure.
Key Highlights
- LB-100 combined with Dostarlimab showed an acceptable safety profile.
- Disease Control Rate (DCR) was 40% (8/20) in evaluated patients.
- Overall Survival (OS) probability was 0.69 at 12 months.
- An additional cohort of 21 patients is enrolling for higher LB-100 exposure.
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