New LaunchMay 26, 2026, 09:08 AM
PacBio Ships SPRQ-Nx Chemistry, Lowers HiFi Genome Cost to $345
AI Summary
PacBio announced the global commercial availability of its SPRQ-Nx sequencing chemistry and new multi-use SMRT Cells for the Revio HiFi sequencing platform. This launch significantly reduces the per-genome list price to $345, with potential for sub-$300 at scale. The company also highlighted advancements in AI-powered DeepConsensus and expanded methylation detection, including a new 5hmC caller, which enhance data quality and biological insights. Beta testing across 20 sites demonstrated strong run performance, increased yield, and lower failure rates.
Key Highlights
- SPRQ-Nx sequencing chemistry and new multi-use SMRT Cells are now shipping worldwide for the Revio HiFi sequencing platform.
- The per genome list price is reduced to $345, with the possibility of sub-$300 HiFi genomes for customers sequencing at scale (5,000 genomes/year).
- Expanded methylation detection includes updated 5mC and 6mA models, and a new 5-hydroxymethyl-cytosine (5hmC) caller.
- DeepConsensus, an AI-powered algorithm developed with Google, received updates optimized by Google's AlphaEvolve, improving accuracy and processing speed.
- Beta testing across 20 sites in Europe, Asia, and the United States involved over 1,400 runs, showing increased yield and lower failure rates.
- PacBio plans to bring SPRQ-Nx chemistry and other platform improvements to its Vega benchtop system later in 2026.
Price Impact
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