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Biotechnology: Pharmaceutical Preparations
Clinical TrialApr 16, 2026, 07:01 AM

Tiziana Reports Positive Preclinical Data for Foralumab in Long COVID

AI Summary

Tiziana Life Sciences announced positive preclinical data for its intranasal foralumab in a Long COVID mouse model. The study, published in bioRxiv, showed that nasal anti-CD3 treatment significantly reduced neuroinflammation, boosted regulatory T cells in the brain, restored hippocampal neurogenesis, and improved short-term memory. These findings suggest a promising, non-invasive strategy to address cognitive impairment in Long COVID patients and support the broad therapeutic potential of foralumab.

Key Highlights

  • Nasal anti-CD3 treatment reduced neuroinflammation in Long COVID mouse model.
  • Increased regulatory T cells (Tregs) in the brain and restored neurogenesis.
  • Improved short-term memory in mice with Long COVID symptoms.
  • Reprogrammed microglia from pro-inflammatory to regulatory phenotype.
  • Human data showed lower circulating Treg levels in Long COVID patients.