
Clinical TrialApr 16, 2026, 07:01 AM
Tiziana Reports Positive Preclinical Data for Foralumab in Long COVID
AI Summary
Tiziana Life Sciences announced positive preclinical data for its intranasal foralumab in a Long COVID mouse model. The study, published in bioRxiv, showed that nasal anti-CD3 treatment significantly reduced neuroinflammation, boosted regulatory T cells in the brain, restored hippocampal neurogenesis, and improved short-term memory. These findings suggest a promising, non-invasive strategy to address cognitive impairment in Long COVID patients and support the broad therapeutic potential of foralumab.
Key Highlights
- Nasal anti-CD3 treatment reduced neuroinflammation in Long COVID mouse model.
- Increased regulatory T cells (Tregs) in the brain and restored neurogenesis.
- Improved short-term memory in mice with Long COVID symptoms.
- Reprogrammed microglia from pro-inflammatory to regulatory phenotype.
- Human data showed lower circulating Treg levels in Long COVID patients.
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