Korro Bio, Inc. Q3 FY25 Results

“Today, we announced that KRRO-110 generated functional M-AAT protein in AATD patients. We’re encouraged by the evidence of clinical activity, which we believe confirms our ability to edit RNA and produce therapeutic proteins in humans. While a single administration of KRRO-110 achieved functional protein production, it did not achieve the protein levels we projected based on preclinical data. Initial analysis indicates differences in the pharmacokinetics of the delivery components observed between healthy volunteers and AATD patients. The valuable insights gained from REWRITE, combined with the significant progress we’ve made in potency, have informed our strategic decision to advance a GalNAc-conjugated construct for AATD. We are on track for a potential development candidate nomination in the first half of 2026.” “In addition, we have nominated our next development candidate, KRRO-121, a GalNAc-conjugated construct that activates a biological pathway by creating a de novo variant, for patients with hyperammonemia. This marks our first step in expanding our proprietary RNA editing platform beyond protein repair. We are working to advance KRRO-121 and a GalNAc version for AATD patients into the clinic in the second half of 2026 and in 2027, respectively.” “To focus our resources on generating clinical data and advancing additional GalNAc-conjugated programs targeting the liver, we are implementing a strategic restructuring that reduces our workforce by approximately a third while extending our cash runway into the second half of 2027. We are grateful for our employees and their commitment. A special thanks to the AATD community, the participants in the REWRITE study, and the investigators who are continuing to work with us as we evaluate next steps for the program. We remain committed to our mission of delivering transformative genetic medicines to patients.”